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Issue 38, 2017
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Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimics

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Abstract

We investigated intra-chain isocyanide-based multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each junction point in order to create materials featuring multiple protein-inspired elements. Upon intramolecular cross-linking, nanoparticle formation ensues, affording materials with well-defined structural elements situated in a disordered tertiary structure. The resulting nanostructures were characterized using 1H NMR, DOSY NMR, and size-exclusion chromatography. While covalent cross-linking was the intended and predominant mode of SCNP formation, we found that secondary, noncovalent interactions contributed significantly to nanoparticle folding more akin to natural materials.

Graphical abstract: Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimics

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Supplementary files

Article information


Submitted
07 Jul 2017
Accepted
06 Aug 2017
First published
07 Aug 2017

Polym. Chem., 2017,8, 5829-5835
Article type
Paper

Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimics

J. P. Cole, J. J. Lessard, K. J. Rodriguez, A. M. Hanlon, E. K. Reville, J. P. Mancinelli and E. B. Berda, Polym. Chem., 2017, 8, 5829
DOI: 10.1039/C7PY01133D

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