Issue 5, 2017

Polypeptides by light: photo-polymerization of N-carboxyanhydrides (NCA)

Abstract

The synthesis of polypeptides by N-carboxyanhydride (NCA) photopolymerization is demonstrated. The active initiator cyclohexylamine was produced in situ by the UV-induced breakdown of photoamine generators. Real-time FTIR and MALDI-ToF-MS analyses provide clear evidence for the proposed photoinitiation mechanism as well as the attachment of the active initiator to the polypeptide chain. NCA photopolymerization generates new possibilities for designing polypeptides both in solution and on surfaces.

Graphical abstract: Polypeptides by light: photo-polymerization of N-carboxyanhydrides (NCA)

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2016
Accepted
20 Dec 2016
First published
21 Dec 2016

Polym. Chem., 2017,8, 828-832

Polypeptides by light: photo-polymerization of N-carboxyanhydrides (NCA)

T. Stukenkemper, J. F. G. A. Jansen, C. Lavilla, A. A. Dias, D. F. Brougham and A. Heise, Polym. Chem., 2017, 8, 828 DOI: 10.1039/C6PY02018F

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