Isatoic anhydride is elaborated to water soluble bioconjugation reagents that gives functionality and water solubility in one self-cleaning step. This new platform offers high atom economy with carbon dioxide being the only byproduct, and is shown to very quickly and efficiently label proteins in bicarbonate buffered solutions.
A. Fessler, C. Garmon, T. Heavey, A. Fowler and C. Ogle, Org. Biomol. Chem., 2017, 15, 9599 DOI: 10.1039/C7OB02377D
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