Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers

Rubén Ruiz-González; Francesca Setaro; Òscar Gulías; Montserrat Agut; Uwe Hahn; Tomás Torres; Santi Nonell

doi:10.1039/C7OB02270K

Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers†

Rubén Ruiz-González,

^a Francesca Setaro,

^b Òscar Gulías,

^a Montserrat Agut,

^a Uwe Hahn,

*^bc Tomás Torres

*^bde and Santi Nonell

*^a

Author affiliations

* Corresponding authors

^a Institut Químic de Sarriá, Universitat Ramon Llull, Barcelona, Spain
E-mail: santi.nonell@iqs.url.edu
Fax: +34 932 056 266
Tel: +34 932 672 000

^b Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Fax: +34 91497 3966
Tel: +34 91497 4151

^c Laboratoire de Chimie des Matériaux Moléculaires, Université de Strasbourg et CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg Cedex 2, France
Fax: +33 368 85 27 64
Tel: +33 368 85 27 64

^d IMDEA-Nanociencia, c/ Faraday, 9, Cantoblanco, 28049 Madrid, Spain

^e Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain

Abstract

In the present study we describe the synthesis, photophysical properties and the photoinactivation performance against representative microorganisms of two families of cationic dendrimeric phthalocyanines as potential photosensitisers. Four charged dendrimeric compounds varying in their degree of ionicity (4 or 8 positive charges) and the coordinating metal (zinc or ruthenium) are compared and assessed as potential photosensitising agents in terms of their antimicrobial activity.

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DOI: https://doi.org/10.1039/C7OB02270K
Article type: Paper
Submitted: 10 Sep 2017
Accepted: 09 Oct 2017
First published: 18 Oct 2017
This article is Open Access

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Org. Biomol. Chem., 2017,15, 9008-9017

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Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers

R. Ruiz-González, F. Setaro, Ò. Gulías, M. Agut, U. Hahn, T. Torres and S. Nonell, Org. Biomol. Chem., 2017, 15, 9008 DOI: 10.1039/C7OB02270K

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Organic & Biomolecular Chemistry

Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers†

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Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers

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