Issue 39, 2017

Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

Abstract

The methodology of direct C(sp2)–H functionalization has for the first time been applied as an efficient and advanced approach to carry out C–H/C–H coupling of 2H-imidazole 1-oxides and pyrroles. The atom-economical method used does not require either any auxiliary group in the starting substrates, or catalysis by transition metals. As a result, a number of novel 1H-pyrrol-2-yl-2H-imidazoles, that are particularly of interest in the design of bioactive molecules, have been prepared under mild conditions and in good to excellent yields.

Graphical abstract: Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

Supplementary files

Article information

Article type
Communication
Submitted
11 Aug 2017
Accepted
12 Sep 2017
First published
13 Sep 2017

Org. Biomol. Chem., 2017,15, 8280-8284

Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

M. Varaksin, T. Moseev, O. Chupakhin, V. Charushin and B. Trofimov, Org. Biomol. Chem., 2017, 15, 8280 DOI: 10.1039/C7OB01999H

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