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Issue 31, 2017
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Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds

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Abstract

Allelochemicals are safer, more selective and more active alternatives than synthetic agrochemicals for weed control. However, the low solubility of these compounds in aqueous media limits their use as agrochemicals. Herein, we propose the application of α-, β- and γ-cyclodextrins to improve the physicochemical properties and biological activities of three sesquiterpene lactones: dehydrocostuslactone, costunolide and (−)-α-santonin. Complexation was achieved by kneading and coprecipitation methods. Aqueous solubility was increased in the range 100–4600% and the solubility–phase diagrams suggested that complex formation had been successful. The results of the PM3 semiempirical calculations were consistent with the experimental results. The activities on etiolated wheat coleoptiles, Standard Target Species and parasitic weeds were improved. Cyclodextrins preserved or enhanced the activity of the three sesquiterpene lactones. Free cyclodextrins did not show significant activity and therefore the enhancement in activity was due to complexation. These results are promising for applications in agrochemical design.

Graphical abstract: Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds

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Supplementary files

Article information


Submitted
08 Jun 2017
Accepted
19 Jul 2017
First published
19 Jul 2017

Org. Biomol. Chem., 2017,15, 6500-6510
Article type
Paper

Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds

A. Cala, J. M. G. Molinillo, M. Fernández-Aparicio, J. Ayuso, J. A. Álvarez, D. Rubiales and F. A. Macías, Org. Biomol. Chem., 2017, 15, 6500
DOI: 10.1039/C7OB01394A

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