Issue 30, 2017

Low pH-triggering changes in peptide secondary structures

Abstract

We developed a novel methodology using cyclic α,α-disubstituted α-amino acids (dAAs) with an acetal-side chain to control peptide secondary structures. The introduction of cyclic dAAs into peptides contributed to the stabilization of peptide secondary structures as a helix, while an acidic treatment of peptides resulted in a marked conformational change.

Graphical abstract: Low pH-triggering changes in peptide secondary structures

Supplementary files

Article information

Article type
Communication
Submitted
06 Jun 2017
Accepted
27 Jun 2017
First published
27 Jun 2017

Org. Biomol. Chem., 2017,15, 6302-6305

Low pH-triggering changes in peptide secondary structures

K. Furukawa, M. Oba, K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi and M. Tanaka, Org. Biomol. Chem., 2017, 15, 6302 DOI: 10.1039/C7OB01374D

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