Issue 29, 2017

Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition

Abstract

A highly efficient [3 + 2] cycloaddition between trifluoromethylated N-acylhydrazones and nitroolefins in the presence of potassium hydroxide under phase transfer catalysis is developed to afford potentially bioactive trifluoromethylated pyrazolidines, which can be further transformed into trifluoromethylated pyrazoles in good yields.

Graphical abstract: Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition

Supplementary files

Article information

Article type
Paper
Submitted
27 May 2017
Accepted
04 Jul 2017
First published
04 Jul 2017

Org. Biomol. Chem., 2017,15, 6214-6222

Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition

X. Peng, D. Huang, K. Wang, Y. Wang, J. Wang, Y. Su and Y. Hu, Org. Biomol. Chem., 2017, 15, 6214 DOI: 10.1039/C7OB01299C

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