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Issue 37, 2017
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Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs

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Abstract

Lipo-chitotetrasaccharide analogues where one central GlcNAc residue was replaced by a triazole unit have been synthesized from a derivative obtained by chitin depolymerization and a functionalized N-acetyl-glucosamine via the copper-catalyzed azide–alkyne cycloaddition. Their evaluation in a binding assay using LYR3, a putative lipo-chitooligosaccharide receptor in Medicago truncatula, shows a complete loss of binding.

Graphical abstract: Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs

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Supplementary files

Article information


Submitted
17 May 2017
Accepted
30 Aug 2017
First published
30 Aug 2017

Org. Biomol. Chem., 2017,15, 7802-7812
Article type
Paper

Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs

N. Berthelot, A. Brossay, V. Gasciolli, J. Bono, A. Baron, J. Beau, D. Urban, F. Boyer and B. Vauzeilles, Org. Biomol. Chem., 2017, 15, 7802
DOI: 10.1039/C7OB01201B

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