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Issue 27, 2017
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Targeting heparin and heparan sulfate protein interactions

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Abstract

Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are made up of alternating dissacharide sequences of sulfated uronic acid and amino sugars. Unlike heparin, which is only found in mast cells, heparan sulfate is ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These negatively-charged glycans play essential roles in important cellular functions such as cell growth, adhesion, angiogenesis, and blood coagulation. These biomolecules are also involved in pathophysiological conditions such as pathogen infection and human disease. This review discusses past and current methods for targeting these complex biomolecules as a novel therapeutic strategy to treating disorders such as cancer, neurodegenerative diseases, and infection.

Graphical abstract: Targeting heparin and heparan sulfate protein interactions

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Article information


Submitted
02 May 2017
Accepted
13 Jun 2017
First published
13 Jun 2017

Org. Biomol. Chem., 2017,15, 5656-5668
Article type
Review Article

Targeting heparin and heparan sulfate protein interactions

R. J. Weiss, J. D. Esko and Y. Tor, Org. Biomol. Chem., 2017, 15, 5656
DOI: 10.1039/C7OB01058C

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