Issue 22, 2017

Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

Abstract

Neobraclactones A–C (1–3), featuring an unprecedented further rearranged prenylxanthone skeleton with a unique octahydro-2H-1,3-dioxacyclopenta[c,d]inden-2-one scaffold, along with their biosynthesis-related known compound neobractatin (4), were isolated from the leaves of Garcinia bracteata. Their structures with absolute configurations were determined by extensive analyses of spectroscopic data and ECD calculations. Compounds 1 and 2 showed significant growth inhibition activities against the human leukaemia HL-60 and K562 cell lines with GI50 values from 0.40 to 0.86 μM.

Graphical abstract: Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

Supplementary files

Article information

Article type
Paper
Submitted
25 Apr 2017
Accepted
18 May 2017
First published
18 May 2017

Org. Biomol. Chem., 2017,15, 4901-4906

Neobraclactones A–C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

S. Niu, D. Li, Y. Wang, K. Wang, B. Lin, Y. Jing, H. Hua, J. Bai and Z. Li, Org. Biomol. Chem., 2017, 15, 4901 DOI: 10.1039/C7OB01007A

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