Niobium(v)-catalyzed defluorinative triallylation of α,α,α-trifluorotoluene derivatives by triple C–F bond activation

Abstract

The catalytic defluorinative triallylation of α,α,α-trifluorotoluene derivatives via C–F bond activation has been achieved by the use of the NbCl₅ catalyst and allyltrimethylsilane as a nucleophile. Several control experiments have suggested the importance of the conjugation between the fluorine atoms and the carbocation center in this reaction.