Jump to main content
Jump to site search

Issue 1, 2017
Previous Article Next Article

Pseudopeptidic compounds for the generation of dynamic combinatorial libraries of chemically diverse macrocycles in aqueous media

Author affiliations

Abstract

A straightforward four-step synthesis leads to the preparation of C2-symmetric dithiols containing a central aromatic core and amino acid side chains. These building blocks allow the preparation of dynamic covalent libraries of pseudopeptidic macrocycles in aqueous media that cover a broad range of polarities, functional groups and bulkiness mirroring the diversity found in natural peptides. The versatility of the generated dynamic libraries has been illustrated by the amplification of two different members from the same library upon the action of two biologically relevant templates.

Graphical abstract: Pseudopeptidic compounds for the generation of dynamic combinatorial libraries of chemically diverse macrocycles in aqueous media

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Nov 2016, accepted on 22 Nov 2016 and first published on 22 Nov 2016


Article type: Paper
DOI: 10.1039/C6OB02441F
Citation: Org. Biomol. Chem., 2017,15, 213-219
  •   Request permissions

    Pseudopeptidic compounds for the generation of dynamic combinatorial libraries of chemically diverse macrocycles in aqueous media

    J. Atcher, J. Solà and I. Alfonso, Org. Biomol. Chem., 2017, 15, 213
    DOI: 10.1039/C6OB02441F

Search articles by author

Spotlight

Advertisements