Issue 5, 2017
From the journal:

Organic & Biomolecular Chemistry

A mitochondria-targeting fluorescent probe for the selective detection of glutathione in living cells†

Xue-Liang Liu,a   Li-Ya Niu,*b   Yu-Zhe Chen,c   Mei-Ling Zheng, ORCID logo c   Yunxu Yang*a  and  Qing-Zheng Yang ORCID logo *b  

* Corresponding authors

a School of Chemistry and biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China
E-mail: yxyang@ustb.edu.cn

b Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China
E-mail: niuly@bnu.edu.cn, qzyang@bnu.edu.cn

c Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

Abstract

We report a fluorescent probe for the selective detection of mitochondrial glutathione (GSH). The probe, containing triphenylphosphine as a mitochondrial targeting group, exhibited ratiometric and selective detection of GSH over Cys/Hcy. The probe was used for imaging mitochondrial GSH in living HeLa cells.

Graphical abstract: A mitochondria-targeting fluorescent probe for the selective detection of glutathione in living cells

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Article information

DOI
https://doi.org/10.1039/C6OB02407F
Article type
Communication
Submitted
04 Nov 2016
Accepted
23 Dec 2016
First published
23 Dec 2016

Org. Biomol. Chem., 2017,15, 1072-1075

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A mitochondria-targeting fluorescent probe for the selective detection of glutathione in living cells

X. Liu, L. Niu, Y. Chen, M. Zheng, Y. Yang and Q. Yang, Org. Biomol. Chem., 2017, 15, 1072 DOI: 10.1039/C6OB02407F

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