Issue 4, 2017

A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study

Abstract

A rhodamine–phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe3+ ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe3+ ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe3+ ions in living C6 cell lines, the results of which demonstrated that probe 4 acts as an efficient fluorescent tool for Fe3+ ion detection in biological systems.

Graphical abstract: A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study

Supplementary files

Article information

Article type
Paper
Submitted
10 Oct 2016
Accepted
22 Dec 2016
First published
23 Dec 2016

Org. Biomol. Chem., 2017,15, 1006-1012

A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study

N. Sharma, S. I. Reja, N. Gupta, V. Bhalla, D. Kaur, S. Arora and M. Kumar, Org. Biomol. Chem., 2017, 15, 1006 DOI: 10.1039/C6OB02209J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements