Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

Fuwu Zhang; Sarosh Khan; Richen Li; Justin A. Smolen; Shiyi Zhang; Guizhi Zhu; Lu Su; Ashlee A. Jahnke; Mahmoud Elsabahy; Xiaoyuan Chen; Karen L. Wooley

doi:10.1039/C7NR05935C

Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading†

Fuwu Zhang,^ab Sarosh Khan,^a Richen Li,^a Justin A. Smolen,^a Shiyi Zhang,^a Guizhi Zhu,^b Lu Su,^a Ashlee A. Jahnke,^a Mahmoud Elsabahy,^ac Xiaoyuan Chen

^b and Karen L. Wooley

*^a

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* Corresponding authors

^a Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, and Texas A&M Institute for Preclinical Studies, Texas A&M University, College Station, Texas 77842, USA
E-mail: wooley@chem.tamu.edu

^b Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA

^c Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt

Abstract

Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL⁻¹. The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.

Nanoscale

Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading†

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Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

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