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Issue 15, 2017

Supercritical fluid extraction of papaverine and noscapine from poppy capsules followed by preconcentration with magnetic nano Fe3O4@Cu@diphenylthiocarbazone particles

Author affiliations

Abstract

A novel magnetite adsorbent modified with copper and diphenylthiocarbazone was synthesized and used as a sorbent for magnetic solid phase extraction (MSPE) of two opium alkaloids: papaverine and noscapine. Supercritical fluid extraction (SFE) was used to extract the analytes from poppy capsules. The extracts were preconcentrated by magnetic solid phase extraction. Separation and determination of both opium alkaloids were performed using high performance liquid chromatography with an ultra-violet detector. The SFE parameters were optimized through a Taguchi orthogonal array experimental design. Under the optimal conditions, broad linear dynamic ranges of 0.3–180 μg L−1 (0.9981 < R2 < 0.9993) and 0.3–4 mg kg−1 (0.9921 < R2 < 0.9971), favorable limits of detection of 1 μg L−1 and 0.1 mg kg−1, and suitable precisions with RSDs% in the range of 4.3–5.5% and 5.8–7.7% were obtained for MSPE and SFE-MSPE, respectively. The capability of the method was tested by analyzing different real samples including urinary samples and poppy capsules.

Graphical abstract: Supercritical fluid extraction of papaverine and noscapine from poppy capsules followed by preconcentration with magnetic nano Fe3O4@Cu@diphenylthiocarbazone particles

Article information


Submitted
08 Mar 2017
Accepted
14 Jun 2017
First published
15 Jun 2017

New J. Chem., 2017,41, 7028-7037
Article type
Paper

Supercritical fluid extraction of papaverine and noscapine from poppy capsules followed by preconcentration with magnetic nano Fe3O4@Cu@diphenylthiocarbazone particles

M. Tajik, Y. Yamini, T. Baheri, M. Safari and H. Asiabi, New J. Chem., 2017, 41, 7028 DOI: 10.1039/C7NJ00776K

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