Copper-catalyzed synthesis of benzo[d][1,3]dioxin-4-ones via tandem Ar–halogen bond hydroxylation and dichloromethane-based double Williamson etherification

Abstract

The reactions of o-halobenzoic acids, dichloromethane and potassium hydroxide providing benzo[d][1,3]dioxin-4-ones have been realized via the catalysis of Cu(OAc)₂. Tandem Ar–X (X = I, Br) bond hydroxylation and double Williamson etherification on dichloromethane are involved during the construction of the target products.