A new ESIPT-based fluorescent probe for highly selective and sensitive detection of hydrogen sulfide and its application in live-cell imaging

Abstract

A new excited-state intramolecular proton transfer (ESIPT) based fluorescent probe for the detection of hydrogen sulfide has been reasonably designed and developed. The probe operates by H₂S-mediated reduction of hydroxylamine to amine and exhibits high selectivity and sensitivity under mild conditions. Furthermore, the probe was successfully used for fluorescence imaging of H₂S in living cells.