Issue 3, 2017
From the journal:

New Journal of Chemistry

In situ formed acetals facilitated direct Michael addition of unactivated ketones†

Srinivasa Rao Koppolua  and  Rengarajan Balamurugan ORCID logo *a  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli, Hyderabad-500046, India
E-mail: rbsc@uohyd.ernet.in
Tel: +91-40-23134817

Abstract

TfOH-promoted synthesis of 1,5-diketones by the Michael reaction of unactivated ketones with chalcones has been described. Acetals formed under HC(OMe)3/TfOH conditions generate the required enol-equivalents for a smooth Michael reaction. A wide array of symmetrical and unsymmetrical 1,5-diketones has been synthesised.

Graphical abstract: In situ formed acetals facilitated direct Michael addition of unactivated ketones

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Article information

DOI
https://doi.org/10.1039/C6NJ02954J
Article type
Paper
Submitted
19 Sep 2016
Accepted
28 Dec 2016
First published
28 Dec 2016

New J. Chem., 2017,41, 1186-1192

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In situ formed acetals facilitated direct Michael addition of unactivated ketones

S. R. Koppolu and R. Balamurugan, New J. Chem., 2017, 41, 1186 DOI: 10.1039/C6NJ02954J

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