Issue 1, 2017
From the journal:

New Journal of Chemistry

Pd-catalyzed intramolecular sequential Heck cyclization and oxidation reactions: a facile pathway for the synthesis of substituted cycloheptenone evaluated using computational studies†

Jayanta K. Ray,*a   Sunanda Paul,a   Paramita Ray,a   Raju Singha,a   Davuluri Yogeswara Rao,a   Surajit Nandi ORCID logo a  and  Anakuthil Anoop ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India
E-mail: jkray@chem.iitkgp.ernet.in
Tel: +91-3222 283326

Abstract

A simple and convenient method for the construction of substituted cycloheptenones from 1-bromoocta-1,7-diene-3-ols has been developed. The reaction involves Pd(0)-catalyzed intramolecular 7-exo-trig cyclization followed by Pd(II)-catalyzed oxidation of cyclic alcohol. The course of the reaction pathway has been evaluated using DFT calculations.

Graphical abstract: Pd-catalyzed intramolecular sequential Heck cyclization and oxidation reactions: a facile pathway for the synthesis of substituted cycloheptenone evaluated using computational studies

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Article information

DOI
https://doi.org/10.1039/C6NJ02694J
Article type
Paper
Submitted
28 Aug 2016
Accepted
08 Nov 2016
First published
10 Nov 2016

New J. Chem., 2017,41, 278-284

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Pd-catalyzed intramolecular sequential Heck cyclization and oxidation reactions: a facile pathway for the synthesis of substituted cycloheptenone evaluated using computational studies

J. K. Ray, S. Paul, P. Ray, R. Singha, D. Y. Rao, S. Nandi and A. Anoop, New J. Chem., 2017, 41, 278 DOI: 10.1039/C6NJ02694J

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