Issue 6, 2017
From the journal:

Materials Horizons

Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells†

Wen Lv,a   Huiting Xia,a   Kenneth Yin Zhang,a   Zejing Chen,a   Shujuan Liu,a   Wei Huang ORCID logo *ab  and  Qiang Zhao*a  

* Corresponding authors

a Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, P. R. China
E-mail: iamqzhao@njupt.edu.cn, wei-huang@njtech.edu.cn

b Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), Xi’an 710072, P. R. China

Abstract

A polymeric carrier containing a naphthalene and iridium(III) complex was developed to deliver extracellular singlet oxygen (1O2) into cancer cells to induce oxidative damage without intracellular O2 consumption. The release of 1O2 was triggered by the photothermal effect of Au nanorods upon irradiation at 808 nm, realizing controllable therapy combining both oxidative and photothermal damage.

Graphical abstract: Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

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Article information

DOI
https://doi.org/10.1039/C7MH00726D
Article type
Communication
Submitted
07 Sep 2017
Accepted
05 Oct 2017
First published
05 Oct 2017

Mater. Horiz., 2017,4, 1185-1189

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Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

W. Lv, H. Xia, K. Y. Zhang, Z. Chen, S. Liu, W. Huang and Q. Zhao, Mater. Horiz., 2017, 4, 1185 DOI: 10.1039/C7MH00726D

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