Degradable gold core–mesoporous organosilica shell nanoparticles for two-photon imaging and gemcitabine monophosphate delivery

Saher Rahmani; Arnaud Chaix; Dina Aggad; Phuong Hoang; Basem Moosa; Marcel Garcia; Magali Gary-Bobo; Clarence Charnay; Abdulaziz AlMalik; Jean-Olivier Durand; Niveen M. Khashab

doi:10.1039/C7ME00058H

Degradable gold core–mesoporous organosilica shell nanoparticles for two-photon imaging and gemcitabine monophosphate delivery†

Saher Rahmani,‡^ab Arnaud Chaix,‡^a Dina Aggad,^c Phuong Hoang,^a Basem Moosa,^a Marcel Garcia,^c Magali Gary-Bobo,^c Clarence Charnay,^b Abdulaziz AlMalik,^d Jean-Olivier Durand

*^b and Niveen M. Khashab

*^a

Author affiliations

* Corresponding authors

^a Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
E-mail: niveen.khashab@kaust.edu.sa

^b Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM, cc 1701, Place Eugène Bataillon, 34095 Montpellier cedex 05, France
E-mail: durand@univ-montp2.fr

^c Institut des Biomolécules Max Mousseron, UMR 5247, Université de Montpellier, Avenue Charles Flahault, 34093 Montpellier cedex 05, France

^d Life Sciences and Environment Research Institute, Center of Excellence in Nanomedicine (CENM), King Abdulaziz City for Science and Technology (KACST), Riyadh 11461, Saudi Arabia

Abstract

The synthesis of degradable gold core–mesoporous organosilica shell nanoparticles is described. The nanoparticles were very efficient for two-photon luminescence imaging of cancer cells and for in vitro gemcitabine monophosphate delivery, allowing promising theranostic applications in the nanomedicine field.

This article is part of the themed collections: Celebrating Excellence in Research: 100 Women of Chemistry and Engineering Nanoparticles for Sensing and Biomedical Applications

Molecular Systems Design & Engineering

Degradable gold core–mesoporous organosilica shell nanoparticles for two-photon imaging and gemcitabine monophosphate delivery†

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Degradable gold core–mesoporous organosilica shell nanoparticles for two-photon imaging and gemcitabine monophosphate delivery

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