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Issue 5, 2017
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An insight into the therapeutic potential of quinazoline derivatives as anticancer agents

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Abstract

Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic drugs are available on the market, and several compounds are in different phases of clinical trials. Many studies suggest that these cytotoxic molecules are also associated with different types of adverse side effects; therefore researchers around the globe are involved in the development of more efficient and safer anticancer drugs. In recent years, quinazoline and its derivatives have been considered as a novel class of cancer chemotherapeutic agents that show promising activity against different tumors. The aim of this article is to comprehensively review and highlight the recent developments concerning the anticancer activity of quinazoline derivatives as well as offer perspectives on the development of novel quinazoline derivatives as anticancer agents in the near future.

Graphical abstract: An insight into the therapeutic potential of quinazoline derivatives as anticancer agents

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Article information


Submitted
25 Feb 2017
Accepted
05 Apr 2017
First published
07 Apr 2017

Med. Chem. Commun., 2017,8, 871-885
Article type
Review Article

An insight into the therapeutic potential of quinazoline derivatives as anticancer agents

Shagufta and I. Ahmad, Med. Chem. Commun., 2017, 8, 871
DOI: 10.1039/C7MD00097A

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