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Issue 2, 2017
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Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents

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Abstract

Due to emerging resistance there is a steady need for new antimalarial drugs. Here, we report a new class of water soluble, non-toxic compounds, aryl-alkyl-lysines, with promising activity against the ring stage of Plasmodium falciparum. The optimal compound perturbed the plasma membrane potential and the digestive vacuole of parasites. In the murine model of malaria (Plasmodium berghei ANKA) the compound was able to increase the survival of mice by at least 5 days by an intra-peritoneal route. Further, the compounds showed no apparent toxicity to mice at the concentration tested.

Graphical abstract: Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents

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Publication details

The article was received on 23 Oct 2016, accepted on 06 Dec 2016 and first published on 16 Dec 2016


Article type: Research Article
DOI: 10.1039/C6MD00589F
Citation: Med. Chem. Commun., 2017,8, 434-439
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    Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents

    C. Ghosh, S. Chaubey, U. Tatu and J. Haldar, Med. Chem. Commun., 2017, 8, 434
    DOI: 10.1039/C6MD00589F

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