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Issue 1, 2017
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On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

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Abstract

We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real-time. In a proof-of-concept study, the system was applied to explore amino-catalyzed reactions, including asymmetric iminium-catalyzed Friedel–Crafts alkylations in microflow and micro confined reaction vessels.

Graphical abstract: On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

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Article information


Submitted
28 Sep 2016
Accepted
23 Nov 2016
First published
23 Nov 2016

This article is Open Access

Lab Chip, 2017,17, 76-81
Article type
Communication

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

J. J. Heiland, R. Warias, C. Lotter, L. Mauritz, P. J. W. Fuchs, S. Ohla, K. Zeitler and D. Belder, Lab Chip, 2017, 17, 76
DOI: 10.1039/C6LC01217E

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