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Issue 12, 2017
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A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation

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Abstract

Biocompatible microparticles are valuable tools in biomedical research for applications such as drug delivery, cell transplantation therapy, and analytical assays. However, their translation into clinical research and the pharmaceutical industry has been slow due to the lack of techniques that can produce microparticles with controlled physicochemical properties at high throughput. We introduce a robust microfluidic platform for the production of relatively homogeneous microdroplets at a generation frequency of up to 3.1 MHz, which is about three orders of magnitude higher than the production rate of a conventional microfluidic drop maker. We demonstrated the successful implementation of our device for production of biocompatible microparticles with various crosslinking mechanisms and cell microencapsulation with high cell viability.

Graphical abstract: A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation

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Supplementary files

Article information


Submitted
22 Dec 2016
Accepted
02 May 2017
First published
11 May 2017

Lab Chip, 2017,17, 2067-2075
Article type
Paper

A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation

S. Akbari, T. Pirbodaghi, R. D. Kamm and P. T. Hammond, Lab Chip, 2017, 17, 2067
DOI: 10.1039/C6LC01568A

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