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Issue 1, 2017
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Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method

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Abstract

In order to realize high contrast imaging with portable devices for potential mobile healthcare, we demonstrate a hand-held smartphone based quantitative phase microscope using the transport of intensity equation method. With a cost-effective illumination source and compact microscope system, multi-focal images of samples can be captured by the smartphone’s camera via manual focusing. Phase retrieval is performed using a self-developed Android application, which calculates sample phases from multi-plane intensities via solving the Poisson equation. We test the portable microscope using a random phase plate with known phases, and to further demonstrate its performance, a red blood cell smear, a Pap smear and monocot root and broad bean epidermis sections are also successfully imaged. Considering its advantages as an accurate, high-contrast, cost-effective and field-portable device, the smartphone based hand-held quantitative phase microscope is a promising tool which can be adopted in the future in remote healthcare and medical diagnosis.

Graphical abstract: Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method

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Publication details

The article was received on 25 Oct 2016, accepted on 29 Nov 2016 and first published on 30 Nov 2016


Article type: Paper
DOI: 10.1039/C6LC01321J
Citation: Lab Chip, 2017,17, 104-109
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    Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method

    X. Meng, H. Huang, K. Yan, X. Tian, W. Yu, H. Cui, Y. Kong, L. Xue, C. Liu and S. Wang, Lab Chip, 2017, 17, 104
    DOI: 10.1039/C6LC01321J

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