On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale†
We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real-time. In a proof-of-concept study, the system was applied to explore amino-catalyzed reactions, including asymmetric iminium-catalyzed Friedel–Crafts alkylations in microflow and micro confined reaction vessels.
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