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Issue 6, 2017
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A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

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Abstract

Diazomethane is a valuable C1-building block for organic synthesis. Due to its intrinsic reactivity and instability, handling of this reagent is associated with serious safety hazards. Herein we present a simple and robust continuous flow process, allowing a safe and on-demand generation of diazomethane with a productivity of 95–117 mmol h−1. The developed two-step process starts from non-hazardous N-methylurea, and generates and consumes N-methyl-N-nitrosourea (MNU) and diazomethane, thus enabling a safe and convenient scale-up to a multi-gram scale in a conventional synthesis laboratory.

Graphical abstract: A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

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Supplementary files

Article information


Submitted
07 Nov 2016
Accepted
09 Dec 2016
First published
09 Dec 2016

Green Chem., 2017,19, 1449-1453
Article type
Paper

A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

H. Lehmann, Green Chem., 2017, 19, 1449
DOI: 10.1039/C6GC03066A

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