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Issue 15, 2017
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One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

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Abstract

An efficient and green method for the synthesis of 2-hydroxymethyl-5-methylpyrazine was achieved from biomass derived 1,3-dihydroxyacetone and diammonium phosphate via a one-pot reaction. The product yield was as high as 72% under optimized conditions of pH = 8.0–9.1 at 90 °C for 1 hour in a dioxane and water mixture as a solvent. A possible reaction mechanism was proposed according to the reaction kinetics, NMR and in situ ATR-IR characterization studies.

Graphical abstract: One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

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Article information


Submitted
24 Feb 2017
Accepted
26 May 2017
First published
26 May 2017

Green Chem., 2017,19, 3515-3519
Article type
Communication

One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

L. Song, M. Zheng, J. Pang, J. Sebastian, W. Wang, M. Qu, J. Zhao, X. Wang and T. Zhang, Green Chem., 2017, 19, 3515
DOI: 10.1039/C7GC00578D

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