Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 5, 2017
Previous Article Next Article

Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

Author affiliations

Abstract

An efficient and green procedure for the synthesis of tetrazines has been developed based on an old chemistry reported by Carboni in 1958. Both symmetric and asymmetric 3,6-disubstituted 1,2,4,5-tetrazines can be obtained in moderate to high yields from the corresponding gem-difluoroalkenes under aerobic conditions at room temperature. This work represents a rare example that ambient air is utilized as an oxidant for the synthesis of tetrazines.

Graphical abstract: Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Dec 2016, accepted on 17 Jan 2017 and first published on 18 Jan 2017


Article type: Paper
DOI: 10.1039/C6GC03494B
Green Chem., 2017,19, 1299-1302

  •   Request permissions

    Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

    Z. Fang, W. Hu, D. Liu, C. Yu and X. Hu, Green Chem., 2017, 19, 1299
    DOI: 10.1039/C6GC03494B

Search articles by author

Spotlight

Advertisements