Issue 4, 2017
From the journal:

Green Chemistry

Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide†

Pei-Zhi Zhang,a   Jian-An Li,a   Ling Zhang,a   Adedamola Shoberu,a   Jian-Ping Zou ORCID logo *a  and  Wei Zhang ORCID logo *b  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, 199 Renai Street, Suzhou, Jiangsu 215123, China
E-mail: jpzou@suda.edu.cn

b Centre for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
E-mail: wei2.zhang@umb.edu

Abstract

A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.

Graphical abstract: Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

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Article information

DOI
https://doi.org/10.1039/C6GC03355E
Article type
Communication
Submitted
06 Dec 2016
Accepted
01 Jan 2017
First published
02 Jan 2017

Green Chem., 2017,19, 919-923

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Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

P. Zhang, J. Li, L. Zhang, A. Shoberu, J. Zou and W. Zhang, Green Chem., 2017, 19, 919 DOI: 10.1039/C6GC03355E

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