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Issue 4, 2017
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Greener solvents for solid-phase synthesis

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Abstract

The use of a variety of green solvents to swell a diverse range of resins used in solid-phase synthesis is investigated. Good swelling is shown to depend on the structure of the resin and the solvent. A modelling approach based on use of a training set of solvents is used to predict which green solvents will, and will not, swell a particular resin. The chemical relevance of the swelling results is confirmed by an experimental study of a solid-supported Ugi reaction carried out in green solvents.

Graphical abstract: Greener solvents for solid-phase synthesis

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Publication details

The article was received on 15 Nov 2016, accepted on 20 Dec 2016 and first published on 21 Dec 2016


Article type: Paper
DOI: 10.1039/C6GC03147A
Citation: Green Chem., 2017,19, 952-962
  • Open access: Creative Commons BY-NC license
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    Greener solvents for solid-phase synthesis

    S. Lawrenson, M. North, F. Peigneguy and A. Routledge, Green Chem., 2017, 19, 952
    DOI: 10.1039/C6GC03147A

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