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Issue 3, 2017
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Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil

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Abstract

Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide, MOD) is a key psychostimulant drug used for the treatment of narcolepsy and other sleep disorders that has a very low addiction liability. Recently, MOD has been clinically investigated for the treatment of cocaine addiction and used by astronauts in long-term space missions. We have developed a synthetic strategy for “smart drug” Modafinil. An efficient atom and step economic (EASE) synthesis has been carried out by the direct reaction of benzhydrol and 2-mercaptoacetamide using the recyclable heterogeneous catalyst Nafion-H along with post-sulfoxidation. This protocol exhibits improved sustainability credentials. We have also developed a superior pre-sulfoxidation approach for the synthesis of Modafinil.

Graphical abstract: Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil

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Article information


Submitted
19 Sep 2016
Accepted
30 Nov 2016
First published
30 Nov 2016

Green Chem., 2017,19, 629-633
Article type
Communication

Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil

S. Maurya, D. Yadav, K. Pratap and A. Kumar, Green Chem., 2017, 19, 629
DOI: 10.1039/C6GC02623K

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