Fe(ii)-Complexation of tripodal hexapeptide ligands with three bidentate triazolylpyridines: induction of metal-centred chirality by peptide macrocyclization

Abstract

Fe(II)-Coordinating peptides, having three bidentate 2-(1,2,3-triazol-4-yl)pyridine moieties at their side-chains, were designed based on the naturally occurring siderophore structures. The C₃-symmetric macrocyclic peptide and an open-chain congener with the same sequence formed Fe(II)–peptide complexes with opposite metal-centred chiralities.