Issue 13, 2017

Plasmon-enhanced fluorescence spectroscopy


Fluorescence spectroscopy with strong emitters is a remarkable tool with ultra-high sensitivity for detection and imaging down to the single-molecule level. Plasmon-enhanced fluorescence (PEF) not only offers enhanced emissions and decreased lifetimes, but also allows an expansion of the field of fluorescence by incorporating weak quantum emitters, avoiding photobleaching and providing the opportunity of imaging with resolutions significantly better than the diffraction limit. It also opens the window to a new class of photostable probes by combining metal nanostructures and quantum emitters. In particular, the shell-isolated nanostructure-enhanced fluorescence, an innovative new mode for plasmon-enhanced surface analysis, is included. These new developments are based on the coupling of the fluorophores in their excited states with localized surface plasmons in nanoparticles, where local field enhancement leads to improved brightness of molecular emission and higher detection sensitivity. Here, we review the recent progress in PEF with an emphasis on the mechanism of plasmon enhancement, substrate preparation, and some advanced applications, including an outlook on PEF with high time- and spatially resolved properties.

Graphical abstract: Plasmon-enhanced fluorescence spectroscopy

Article information

Article type
Review Article
06 Mar 2017
First published
22 Jun 2017

Chem. Soc. Rev., 2017,46, 3962-3979

Plasmon-enhanced fluorescence spectroscopy

J. Li, C. Li and R. F. Aroca, Chem. Soc. Rev., 2017, 46, 3962 DOI: 10.1039/C7CS00169J

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