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Issue 10, 2017

Benzodiazines: recent synthetic advances

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Abstract

Benzodiazines (diazonaphthalenes with both nitrogens in the same ring) – cinnolines (1,2-benzodiazine), quinazolines (1,3-benzodiazine), phthalazines (2,3-benzodiazine) and quinoxalines (1,4-benzodiazine) – are important class of compounds with broad biological properties and wide application in pharmaceutical as well as agrochemical arenas. These diazaheterocycles are present in a wide variety of bioactive natural products as well as synthetic molecules that are good drug candidates constituting key structural units responsible for their pronounced therapeutic activities. Their rapidly growing uses and applications in medicinal and agrochemical arenas prompt the researchers for further studies on this important group of compounds. In this review, we hope to provide a brief overview of the important general methodologies and recent developments towards their synthesis and open the door for further progress in this area.

Graphical abstract: Benzodiazines: recent synthetic advances

Article information


Submitted
31 Jan 2017
First published
28 Apr 2017

Chem. Soc. Rev., 2017,46, 3060-3094
Article type
Review Article

Benzodiazines: recent synthetic advances

T. Mathew, A. Á. Papp, F. Paknia, S. Fustero and G. K. Surya Prakash, Chem. Soc. Rev., 2017, 46, 3060 DOI: 10.1039/C7CS00082K

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