Jump to main content
Jump to site search

Issue 8, 2017
Previous Article Next Article

Fluorescent bioimaging of pH: from design to applications

Author affiliations


Protons play crucial roles in many physiological and pathological processes, such as receptor-mediated signal transduction, ion transport, endocytosis, homeostasis, cell proliferation, and apoptosis. The urgent demand for pH imaging and measurement in biological systems has incited the development of fluorescent pH probes. Numerous fluorescent probes have been reported, but many lack the abilities needed for biological applications. Hence, the development of new pH probes with better biocompatibility, sensitivity, and site-specificity is still indispensable. This review highlights the recent trends in the development of fluorescent materials as essential tools for tracing pH variations in the biological processes of diverse living systems.

Graphical abstract: Fluorescent bioimaging of pH: from design to applications

Back to tab navigation

Publication details

The article was received on 06 Oct 2016 and first published on 20 Mar 2017

Article type: Tutorial Review
DOI: 10.1039/C6CS00719H
Citation: Chem. Soc. Rev., 2017,46, 2076-2090

  •   Request permissions

    Fluorescent bioimaging of pH: from design to applications

    J. Hou, W. X. Ren, K. Li, J. Seo, A. Sharma, X. Yu and J. S. Kim, Chem. Soc. Rev., 2017, 46, 2076
    DOI: 10.1039/C6CS00719H

Search articles by author