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Issue 41, 2017
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High-resolution microstrip NMR detectors for subnanoliter samples

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Abstract

We present the numerical optimization and experimental characterization of two microstrip-based nuclear magnetic resonance (NMR) detectors. The first detector, introduced in our previous work, was a flat wire detector with a strip resting on a substrate, and the second detector was created by adding a ground plane on top of the strip conductor, separated by a sample-carrying capillary and a thin layer of insulator. The dimensional parameters of the detectors were optimized using numerical simulations with regards to radio frequency (RF) sensitivity and homogeneity, with particular attention given to the effect of the ground plane. The influence of copper surface finish and substrate surface on the spectral resolution was investigated, and a resolution of 0.8–1.5 Hz was obtained on 1 nL deionized water depending on sample positioning. For 0.13 nmol sucrose (0.2 M in 0.63 nL H2O) encapsulated between two Fluorinert plugs, high RF homogeneity (A810°/A90° = 70–80%) and high sensitivity (expressed in the limit of detection nLODm = 0.73–1.21 nmol s1/2) were achieved, allowing for high-performance 2D NMR spectroscopy of subnanoliter samples.

Graphical abstract: High-resolution microstrip NMR detectors for subnanoliter samples

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Article information


Submitted
13 Jun 2017
Accepted
05 Oct 2017
First published
06 Oct 2017

Phys. Chem. Chem. Phys., 2017,19, 28163-28174
Article type
Paper

High-resolution microstrip NMR detectors for subnanoliter samples

Y. Chen, H. S. Mehta, M. C. Butler, E. D. Walter, P. N. Reardon, R. S. Renslow, K. T. Mueller and N. M. Washton, Phys. Chem. Chem. Phys., 2017, 19, 28163
DOI: 10.1039/C7CP03933F

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