Jump to main content
Jump to site search

Issue 45, 2017
Previous Article Next Article

Raman microspectroscopy and multivariate data analysis: optical differentiation of aqueous d- and l-tryptophan solutions

Author affiliations

Abstract

The combination of Raman spectroscopy as a sensitive and selective optical measurement technique and multivariate data analysis forms a powerful tool for probing intermolecular interactions between enantiomers. In this study we demonstrate that the optical differentiation of aqueous D- and L-tryptophan solutions is possible using Raman spectroscopy and principal component analysis (PCA). The loadings of the PCA allow identifying these functional groups most relevant for enantiospecific interactions. Through a partial least squares regression (PLSR) a calibration line can be established for the mixing ratio of ternary aqueous D- and L-tryptophan solutions.

Graphical abstract: Raman microspectroscopy and multivariate data analysis: optical differentiation of aqueous d- and l-tryptophan solutions

Back to tab navigation

Supplementary files

Article information


Submitted
10 Apr 2017
Accepted
18 Oct 2017
First published
20 Oct 2017

Phys. Chem. Chem. Phys., 2017,19, 30533-30539
Article type
Paper

Raman microspectroscopy and multivariate data analysis: optical differentiation of aqueous D- and L-tryptophan solutions

H. Koch, S. Polepil, K. Eisen and S. Will, Phys. Chem. Chem. Phys., 2017, 19, 30533
DOI: 10.1039/C7CP02321A

Social activity

Search articles by author

Spotlight

Advertisements