Issue 95, 2017
From the journal:

Chemical Communications

Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells†

Meng Tian, ORCID logo ‡a   Juanjuan Li,‡a   Shumiao Zhang,a   Lihua Guo,a   Xiangdong He,a   Deliang Kong,a   Hairong Zhanga  and  Zhe Liu ORCID logo *a  

* Corresponding authors

a Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China
E-mail: liuzheqd@163.com

Abstract

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

Graphical abstract: Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells

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Article information

DOI
https://doi.org/10.1039/C7CC08270C
Article type
Communication
Submitted
26 Oct 2017
Accepted
06 Nov 2017
First published
07 Nov 2017

Chem. Commun., 2017,53, 12810-12813

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Half-sandwich ruthenium(II) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells

M. Tian, J. Li, S. Zhang, L. Guo, X. He, D. Kong, H. Zhang and Z. Liu, Chem. Commun., 2017, 53, 12810 DOI: 10.1039/C7CC08270C

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