Issue 100, 2017
From the journal:

Chemical Communications

A chemoselective cleavable fluorescence turn-ON linker for proteomic studies†

Si Si Liew,a   Shubo Du,a   Jingyan Ge,b   Sijun Pan,a   Se-Young Jang,c   Jun-Seok Lee ORCID logo *c  and  Shao Q. Yao ORCID logo *a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmyaosq@nus.edu.sg

b Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, China

c Molecular Recognition Research Center & Department of Biological Chemistry, KIST-School UST, Korea Institute of Science & Technology, South Korea
E-mail: junseoklee@kist.re.kr

Abstract

We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.

Graphical abstract: A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

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Article information

DOI
https://doi.org/10.1039/C7CC08235E
Article type
Communication
Submitted
25 Oct 2017
Accepted
24 Nov 2017
First published
24 Nov 2017

Chem. Commun., 2017,53, 13332-13335

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A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

S. S. Liew, S. Du, J. Ge, S. Pan, S. Jang, J. Lee and S. Q. Yao, Chem. Commun., 2017, 53, 13332 DOI: 10.1039/C7CC08235E

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