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Issue 91, 2017
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Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

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Abstract

By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (−)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.

Graphical abstract: Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

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Article information


Submitted
06 Sep 2017
Accepted
17 Oct 2017
First published
17 Oct 2017

Chem. Commun., 2017,53, 12262-12265
Article type
Communication

Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

G. Mazzoccanti, O. H. Ismail, I. D’Acquarica, C. Villani, C. Manzo, M. Wilcox, A. Cavazzini and F. Gasparrini, Chem. Commun., 2017, 53, 12262
DOI: 10.1039/C7CC06999E

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