Issue 90, 2017
From the journal:

Chemical Communications

A novel, rapid, and sensitive homogeneous sandwich detection method of Glypican-3 as a serum marker for hepatocellular carcinoma†

Naihan Han,a   Wenshuang Wang,a   Danrong Lu,a   Han Wang,a   Xinying Ma,b   Xiaopeng Fan*c  and  Fuchuan Li ORCID logo *a  

* Corresponding authors

a National Glycoengineering Research Center, and Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Jinan 250100, P. R. China
E-mail: fuchuanli@sdu.edu.cn

b Department of Chemistry and Chemical Engineering, Heze University, Heze 274015, P. R. China

c Department of Hepatology, Qilu Hospital, Shandong University, Jinan 250100, P. R. China
E-mail: fxphh@126.com

Abstract

Based on multiple interactions and fluorescence quenching, we report a novel homogeneous detection method for Glypican-3 which shows a series of significant advantages, including low cost, ease of preparation, rapid response, and high sensitivity and has great potential in the clinical diagnosis of hepatocellular carcinoma and proteoglycan detection.

Graphical abstract: A novel, rapid, and sensitive homogeneous sandwich detection method of Glypican-3 as a serum marker for hepatocellular carcinoma

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Article information

DOI
https://doi.org/10.1039/C7CC06305A
Article type
Communication
Submitted
11 Aug 2017
Accepted
18 Oct 2017
First published
20 Oct 2017

Chem. Commun., 2017,53, 12209-12212

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A novel, rapid, and sensitive homogeneous sandwich detection method of Glypican-3 as a serum marker for hepatocellular carcinoma

N. Han, W. Wang, D. Lu, H. Wang, X. Ma, X. Fan and F. Li, Chem. Commun., 2017, 53, 12209 DOI: 10.1039/C7CC06305A

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