Issue 73, 2017
From the journal:

Chemical Communications

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate†

Jiawang Wang, ORCID logo a   Jianhong Zhao*b  and  Hegui Gong ORCID logo *a  

* Corresponding authors

a Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China
E-mail: hegui_gong@shu.edu.cn

b Laboratory of Green Pharmaceutical Process & Technology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
E-mail: zjhpharm@163.com

Abstract

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with methyl tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes.

Graphical abstract: Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

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Article information

DOI
https://doi.org/10.1039/C7CC06106D
Article type
Communication
Submitted
04 Aug 2017
Accepted
23 Aug 2017
First published
23 Aug 2017

Chem. Commun., 2017,53, 10180-10183

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Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

J. Wang, J. Zhao and H. Gong, Chem. Commun., 2017, 53, 10180 DOI: 10.1039/C7CC06106D

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