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Issue 76, 2017
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Specific and spatial labeling of choline-containing teichoic acids in Streptococcus pneumoniae by click chemistry

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Abstract

Propargyl-choline was efficiently incorporated into teichoic acid (TA) polymers on the surface of Streptococcus pneumoniae. The introduction of a fluorophore by click chemistry enabled sufficient labeling of the pneumococcus, as well as its specific detection when mixed with other bacterial species. The labeling is localized at the septal site, suggesting a similar location of the TA and peptidoglycan (PG) synthetic machineries. This method is a unique opportunity to improve our understanding of the spatial location of pneumococcal TA biosynthesis.

Graphical abstract: Specific and spatial labeling of choline-containing teichoic acids in Streptococcus pneumoniae by click chemistry

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Article information


Submitted
20 Jul 2017
Accepted
04 Sep 2017
First published
05 Sep 2017

Chem. Commun., 2017,53, 10572-10575
Article type
Communication

Specific and spatial labeling of choline-containing teichoic acids in Streptococcus pneumoniae by click chemistry

A. M. Di Guilmi, J. Bonnet, S. Peiβert, C. Durmort, B. Gallet, T. Vernet, N. Gisch and Y.-S. Wong, Chem. Commun., 2017, 53, 10572
DOI: 10.1039/C7CC05646J

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