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Issue 77, 2017
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Visible-light-mediated oxidative demethylation of N6-methyl adenines†

Li-Jun Xie,ac   Rui-Li Wang,ac   Dong Wang,a   Li Liuac  and  Liang Cheng ORCID logo *abc  
Author affiliations

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: chengl@iccas.ac.cn

b Key Lab of Functional Molecular Engineering of Guangdong Province (South China University of Technology), Guangzhou 510640, China

c University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

We report a simple protocol that affords oxidative demethylation of N6-methyl groups in N6-methyl adenines (m6A). The biologically compatible photocatalyst riboflavin prompts a highly selective C–H abstraction from N6-methyl in adenines under the irradiation of a visible blue LED light, affording a novel and highly selective biomimetic demethylation of m6A and related N-methyl adenine analogues.

Graphical abstract: Visible-light-mediated oxidative demethylation of N6-methyl adenines

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Article information

https://doi.org/10.1039/C7CC05544G
Submitted
18 Jul 2017
Accepted
11 Sep 2017
First published
18 Sep 2017
Chem. Commun., 2017,53, 10734-10737
Article type
Communication
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Visible-light-mediated oxidative demethylation of N6-methyl adenines

L. Xie, R. Wang, D. Wang, L. Liu and L. Cheng, Chem. Commun., 2017, 53, 10734
DOI: 10.1039/C7CC05544G

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