Visible-light-mediated oxidative demethylation of N6-methyl adenines

Li-Jun Xie; Rui-Li Wang; Dong Wang; Li Liu; Liang Cheng

doi:10.1039/C7CC05544G

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Visible-light-mediated oxidative demethylation of N⁶-methyl adenines†

Li-Jun Xie,^ac Rui-Li Wang,^ac Dong Wang,^a Li Liu^ac and Liang Cheng

*^abc

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: chengl@iccas.ac.cn

^b Key Lab of Functional Molecular Engineering of Guangdong Province (South China University of Technology), Guangzhou 510640, China

^c University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

We report a simple protocol that affords oxidative demethylation of N⁶-methyl groups in N⁶-methyl adenines (m⁶A). The biologically compatible photocatalyst riboflavin prompts a highly selective C–H abstraction from N⁶-methyl in adenines under the irradiation of a visible blue LED light, affording a novel and highly selective biomimetic demethylation of m⁶A and related N-methyl adenine analogues.

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Article information

DOI: https://doi.org/10.1039/C7CC05544G
Article type: Communication
Submitted: 18 Jul 2017
Accepted: 11 Sep 2017
First published: 18 Sep 2017

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Chem. Commun., 2017,53, 10734-10737

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Visible-light-mediated oxidative demethylation of N⁶-methyl adenines

L. Xie, R. Wang, D. Wang, L. Liu and L. Cheng, Chem. Commun., 2017, 53, 10734 DOI: 10.1039/C7CC05544G

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