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Issue 77, 2017
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Visible-light-mediated oxidative demethylation of N6-methyl adenines

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Abstract

We report a simple protocol that affords oxidative demethylation of N6-methyl groups in N6-methyl adenines (m6A). The biologically compatible photocatalyst riboflavin prompts a highly selective C–H abstraction from N6-methyl in adenines under the irradiation of a visible blue LED light, affording a novel and highly selective biomimetic demethylation of m6A and related N-methyl adenine analogues.

Graphical abstract: Visible-light-mediated oxidative demethylation of N6-methyl adenines

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Publication details

The article was received on 18 Jul 2017, accepted on 11 Sep 2017 and first published on 18 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC05544G
Chem. Commun., 2017,53, 10734-10737

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    Visible-light-mediated oxidative demethylation of N6-methyl adenines

    L. Xie, R. Wang, D. Wang, L. Liu and L. Cheng, Chem. Commun., 2017, 53, 10734
    DOI: 10.1039/C7CC05544G

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