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Issue 82, 2017
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Platinum(iv) oxaliplatin–peptide conjugates targeting memHsp70+ phenotype in colorectal cancer cells

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Abstract

Novel Pt(IV) tumour penetrating peptide (TPP) conjugates are reported. They are the first example of metallodrugs to target a membrane bound heat shock protein 70 positive (memHSP70+) phenotype in cancer cells. The conjugates exhibit superior cytotoxicity as compared to oxaliplatin alone in Pt resistant colorectal cancer cells with relatively high memHSP70+ expression. Substitution of TPP in Pt(IV) peptide conjugates with scrambled peptide (ScP) essentially abolishes the observed cytotoxicity.

Graphical abstract: Platinum(iv) oxaliplatin–peptide conjugates targeting memHsp70+ phenotype in colorectal cancer cells

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Publication details

The article was received on 19 Jun 2017, accepted on 25 Sep 2017 and first published on 25 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC04764A
Chem. Commun., 2017,53, 11318-11321

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    Platinum(IV) oxaliplatin–peptide conjugates targeting memHsp70+ phenotype in colorectal cancer cells

    A. M. McKeon, J. Noonan, M. Devocelle, B. M. Murphy and D. M. Griffith, Chem. Commun., 2017, 53, 11318
    DOI: 10.1039/C7CC04764A

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