Jump to main content
Jump to site search

Issue 73, 2017
Previous Article Next Article

Bio-catalytic nanocompartments for in situ production of glucose-6-phosphate

Author affiliations

Abstract

Cells are sophisticated biocatalytic systems driving a complex network of biochemical reactions. A bioinspired strategy to create advanced functional systems is to design confined spaces for complex enzymatic reactions by using a combination of synthetic polymer assemblies and natural cell components. Here, we developed bio-catalytic nanocompartments that contain phosphoglucomutase protected by a biomimetic polymer membrane, which was permeabilized for reactants through insertion of an engineered α-hemolysin pore protein. These bio-catalytic nanocompartments serve for production of glucose-6-phosphate, and thus possess great potential for applications in an incomplete glycolysis, pentose phosphate pathway, or in plant biological reactions.

Graphical abstract: Bio-catalytic nanocompartments for in situ production of glucose-6-phosphate

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Jun 2017, accepted on 22 Aug 2017 and first published on 22 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC04739H
Chem. Commun., 2017,53, 10148-10151

  •   Request permissions

    Bio-catalytic nanocompartments for in situ production of glucose-6-phosphate

    M. Lomora, G. Gunkel-Grabole, S. Mantri and C. G. Palivan, Chem. Commun., 2017, 53, 10148
    DOI: 10.1039/C7CC04739H

Search articles by author

Spotlight

Advertisements